XRCC6 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of XRCC6.
Immunogen
A synthetic peptide corresponding to human XRCC6.
Sequence
YKTEGDEEAEEEQ-C
Host
Goat
Theoretical MW (kDa)
69.8
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
XRCC6 polyclonal antibody (Cat # PAB7303) (0.1 ug/mL) staining of HeLa cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Transfected lysate)
293 overexpressing XRCC6 and probed with XRCC6 polyclonal antibody (Cat # PAB7303) (mock transfection in first lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
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Gene Info — XRCC6
Entrez GeneID
2547Protein Accession#
NP_001460.1Gene Name
XRCC6
Gene Alias
CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 6
Omim ID
152690Gene Ontology
HyperlinkGene Summary
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq
Other Designations
ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|Ku autoantigen p70 subunit|Ku autoantigen, 70kDa|OTTHUMP00000028581|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen
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Interactome
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Pathway
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Disease
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Publication Reference
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Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions.
Ribes-Zamora A, Mihalek I, Lichtarge O, Bertuch AA.
Nature Structural & Molecular Biology 2007 Apr; 14(4):301.
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Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions.
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