PPARGC1A polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PPARGC1A.
Immunogen
A synthetic peptide corresponding to internal region of human PPARGC1A.
Sequence
C-DGLFDDSEDESDK
Host
Goat
Reactivity
Rat
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PPARGC1A polyclonal antibody (Cat # PAB7302) (0.1 ug/mL) staining of rat stomach lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PPARGC1A
Entrez GeneID
10891Protein Accession#
NP_0.37393.1Gene Name
PPARGC1A
Gene Alias
LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
Gene Description
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Omim ID
604517Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq
Other Designations
OTTHUMP00000123372|PPAR gamma coactivator variant form|PPAR gamma coactivator-1|ligand effect modulator-6|peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
Christoph Handschin, Yvonne M Kobayashi, Sherry Chin, Patrick Seale, Kevin P Campbell, Bruce M Spiegelman.
Genes & Development 2007 Apr; 21(7):770.
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PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
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