CACNA2D1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
CACNA2D1 polyclonal antibody (Cat # PAB7294) (0.03 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CACNA2D1.
Immunogen
A synthetic peptide corresponding to internal region of human CACNA2D1.
Sequence
C-QEIFNKYNKDKKVR
Host
Goat
Theoretical MW (kDa)
123
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (0.03-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CACNA2D1 polyclonal antibody (Cat # PAB7294) (0.03 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CACNA2D1
Entrez GeneID
781Protein Accession#
NP_000713.2Gene Name
CACNA2D1
Gene Alias
CACNA2, CACNL2A, CCHL2A, MHS3
Gene Description
calcium channel, voltage-dependent, alpha 2/delta subunit 1
Omim ID
114204Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
H_DJ0560O14.1|WUGSC:H_DJ0560O14.1|calcium channel, L type, alpha 2 polypeptide|dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.
Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, Friedrich Khan I, Rottlander D, Hoppe UC, Mohacsi P, Schmitteckert E, Gilsbach R, Bunemann M, Hein L, Schwartz A, Herzig S.
PLoS One 2007 Mar; 2(3):e292.
Application：WB-Ti, Human, Mouse, Human, mouse cardiac ventricular protein samples.
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Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.
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