CSNK1E polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CSNK1E.
Immunogen
A synthetic peptide corresponding to human CSNK1E.
Sequence
C-PASQTSVPFDHLGK
Host
Goat
Theoretical MW (kDa)
47.3
Reactivity
Human
Specificity
Both reported variants represent identical protein (NP_001885.1 and NP_689407.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 overexpressing CSNK1E and probed with CSNK1E polyclonal antibody (Cat # PAB7264) (mock transfection in first lane) .Enzyme-linked Immunoabsorbent Assay
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Gene Info — CSNK1E
Entrez GeneID
1454Protein Accession#
NP_001885.1;NP_689407.1Gene Name
CSNK1E
Gene Alias
HCKIE, MGC10398
Gene Description
casein kinase 1, epsilon
Omim ID
600863Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
CKI-epsilon|OTTHUMP00000063258|OTTHUMP00000063263|casein kinase 1 epsilon|casein kinase I epsilon
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Interactome
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Pathway
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Disease
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Publication Reference
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A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/beta-catenin complex.
Hammerlein A, Weiske J, Huber O.
Cellular and Molecular Life Sciences 2005 Mar; 62(5):606.
Application:WB-Tr, Human, HEK 293 cells.
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A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/beta-catenin complex.
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