APBA1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of APBA1.
Immunogen
A synthetic peptide corresponding to human APBA1.
Sequence
C-EASHPSQDGKRQYK
Host
Goat
Theoretical MW (kDa)
92.9
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
APBA1 polyclonal antibody (Cat # PAB7261) (0.1 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — APBA1
Entrez GeneID
320Protein Accession#
NP_001154.2Gene Name
APBA1
Gene Alias
D9S411E, MINT1, X11, X11A, X11ALPHA
Gene Description
amyloid beta (A4) precursor protein-binding, family A, member 1
Omim ID
602414Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq
Other Designations
OTTHUMP00000021438|adaptor protein X11alpha|amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)|amyloid beta A4 precursor protein-binding, family A, member 1|neuron-specific X11 protein|neuronal munc18-1-interacting protein 1|phosphotyro
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Interactome
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Disease
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Publication Reference
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Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease.
Jacobs EH, Williams RJ, Francis PT.
Neuroscience 2006 Jan; 138(2):511.
Application:WB-Ti, Human, Human cortex.
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Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease.
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