HNF1A polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HNF1A.
Immunogen
A synthetic peptide corresponding to human HNF1A.
Sequence
C-DELPTKKGRRNRFK
Host
Goat
Theoretical MW (kDa)
67.4
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HNF1A
Entrez GeneID
6927Protein Accession#
NP_000536.3Gene Name
HNF1A
Gene Alias
HNF1, LFB1, MODY3, TCF1
Gene Description
HNF1 homeobox A
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. [provided by RefSeq
Other Designations
Interferon production regulator factor (HNF1)|albumin proximal factor|hepatic nuclear factor 1|maturity onset diabetes of the young 3|transcription factor 1, hepatic|transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal f
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Interactome
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Pathway
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Disease
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Publication Reference
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Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.
Hansen SK, Parrizas M, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T.
The Journal of Clinical Investigation 2002 Sep; 110(6):827.
Application:EMSA, Human, Mouse, Pancreatic.
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Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.
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