HNF1B polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HNF1B.
Immunogen
A synthetic peptide corresponding to internal region of human HNF1B.
Sequence
C-QAYDRQKNPSKEER
Host
Goat
Theoretical MW (kDa)
61.3
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_000449.1; NP_001159395.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
HNF1B polyclonal antibody (Cat # PAB7189) (0.1 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunocytochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HNF1B
Entrez GeneID
6928Protein Accession#
NP_000449.1;NP_006472.1Gene Name
HNF1B
Gene Alias
FJHN, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF2, VHNF1
Gene Description
HNF1 homeobox B
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene
Other Designations
transcription factor 2|transcription factor 2, hepatic|transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells.
Arenas F, Hervias I, Uriz M, Joplin R, Prieto J, Medina JF.
The Journal of Clinical Investigation 2008 Feb; 118(2):695.
Application:WB-Ce, WB-Ti, Human, Human liver, PLC/PRF/5 cells.
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Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells.
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