AIRE polyclonal antibody (Cat # PAB7187) (0.3 ug/mL) staining of human spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot (Transfected lysate)
AIRE polyclonal antibody (Cat # PAB7187) staining (0.05 ug/mL) of HEK293 cell lysates. Transfected with human AIRE (lane 1) and untransfected (Lane2). Data kindly provided by Prof. Part Peterson, University of Tartu, Estonia.
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). [provided by RefSeq