Products

Western Blot (Tissue lysate)

GALR2 polyclonal antibody (Cat # PAB7174) (0.3 ug/mL) staining of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

8811

Protein Accession#

NP_0.03848.1

Gene Name

GALR2

Gene Alias

GALNR2, MGC125983, MGC125984

Gene Description

galanin receptor 2

Omim ID

603691

Gene Ontology

Hyperlink

Gene Summary

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq

Other Designations

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