RAD9A polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RAD9A.
Immunogen
A synthetic peptide corresponding to human RAD9A.
Sequence
C-QGPSPVLAEDSEGE
Host
Goat
Theoretical MW (kDa)
42.5
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
RAD9A polyclonal antibody (Cat # PAB7169) (0.3 ug/mL) staining of A-431 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RAD9A
Entrez GeneID
5883Protein Accession#
NP_004575.1Gene Name
RAD9A
Gene Alias
RAD9
Gene Description
RAD9 homolog A (S. pombe)
Omim ID
603761Gene Ontology
HyperlinkGene Summary
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq
Other Designations
RAD9 homolog|cell cycle checkpoint control protein
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Interactome
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Disease
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Publication Reference
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The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation.
Brandt PD, Helt CE, Keng PC, Bambara RA.
Biochemical and Biophysical Research Communications 2006 Aug; 347(1):232.
Application:WB-Tr, Human, NCI-H1299 cells.
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The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation.
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