GJB2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GJB2.
Immunogen
A synthetic peptide corresponding to human GJB2.
Sequence
YLLIRYCSGKSKKP
Host
Goat
Theoretical MW (kDa)
26.2
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.01-0.03 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GJB2 polyclonal antibody (Cat # PAB7162) (0.01 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GJB2
Entrez GeneID
2706Protein Accession#
NP_0.03995.2Gene Name
GJB2
Gene Alias
CX26, DFNA3, DFNB1, HID, KID, NSRD1, PPK
Gene Description
gap junction protein, beta 2, 26kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq
Other Designations
OTTHUMP00000018093|OTTHUMP00000018094|connexin 26|gap junction protein beta 2|gap junction protein, beta 2, 26kD (connexin 26)
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Interactome
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Disease
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Publication Reference
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Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response.
Djalilian AR, McGaughey D, Patel S, Seo EY, Yang C, Cheng J, Tomic M, Sinha S, Ishida-Yamamoto A, Segre JA.
The Journal of Clinical Investigation 2006 May; 116(5):1243.
Application:IF, IHC-Fr, IHC-P, Mouse, Mouse skin.
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Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response.
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