CACNB4 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
CACNB4 polyclonal antibody (Cat # PAB7161) (0.2 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CACNB4.
Immunogen
A synthetic peptide corresponding to human CACNB4.
Sequence
C-DYPDSYQDTYKPH
Host
Goat
Theoretical MW (kDa)
54.7, 58.2, 56.4
Reactivity
Human
Specificity
This antibody is expected to recognize all three reported isoforms (NP_001005747.1, NP_000717.2, NP_001005746.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western Blot (0.2-0.6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CACNB4 polyclonal antibody (Cat # PAB7161) (0.2 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CACNB4
Entrez GeneID
785Protein Accession#
NP_001005747.1;NP_000717.2;NP_001005746.1Gene Name
CACNB4
Gene Alias
CAB4, CACNLB4, EA5, EJM
Gene Description
calcium channel, voltage-dependent, beta 4 subunit
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
dihydropyridine-sensitive L-type, calcium channel beta-4 subunit|voltage dependent calcium channel beta 4 subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic.
Escayg A, Jones JM, Kearney JA, Hitchcock PF, Meisler MH.
Genomics 1998 May; 50(1):14.
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Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic.
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