HAP1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HAP1.
Immunogen
A synthetic peptide corresponding to human HAP1.
Sequence
C-RYDFRYSEDREQ
Host
Goat
Theoretical MW (kDa)
75.5, 69.6
Reactivity
Human
Specificity
This antibody is expected to recognize all reported isoforms (NP_0.03940.1, NP_817084.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
HAP1 polyclonal antibody (Cat # PAB7160) (0.1 ug/mL) staining of human brain (hippocampus) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HAP1
Entrez GeneID
9001Protein Accession#
NP_0.03940.2;NP_817084.1Gene Name
HAP1
Gene Alias
HAP2, HIP5, HLP, hHLP1
Gene Description
huntingtin-associated protein 1
Omim ID
600947Gene Ontology
HyperlinkGene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000164747|huntingtin-associated protein 2|neuroan 1
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Interactome
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Disease
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Publication Reference
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Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis.
Takeshita Y, Fujinaga R, Zhao C, Yanai A, Shinoda K.
Human Molecular Genetics 2006 Aug; 15(15):2298.
Application:IF, WB, Human, HEp-2 cells.
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Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis.
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