PIN1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PIN1.
Immunogen
A synthetic peptide corresponding to human PIN1.
Sequence
C-KHSQSRRPSSWRQEKITR
Host
Goat
Theoretical MW (kDa)
18.2
Reactivity
Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.2-0.6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PIN1 polyclonal antibody (Cat # PAB7131) (0.2 ug/mL) staining of rat brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PIN1
Entrez GeneID
5300Protein Accession#
NP_006212.1Gene Name
PIN1
Gene Alias
DOD, UBL5
Gene Description
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Omim ID
601052Gene Ontology
HyperlinkGene Summary
The human PIN1 gene encodes an essential nuclear peptidylprolyl cis-trans isomerase (PPIase; EC 5.2.1.8) involved in regulation of mitosis. PIN1 belongs to a class of PPIases that includes the E. coli parvulin, yeast Ess1, and Drosophila dodo (dod) gene products (Lu et al., 1996 [PubMed 8606777]).[supplied by OMIM
Other Designations
peptidyl-prolyl cis/trans isomerase, NIMA-interacting|prolyl isomerase|protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1|protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
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Interactome
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Disease
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Publication Reference
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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP.
Nature 2006 Mar; 440(7083):528.
Application:IF, WB-Tr, Monkey, Mouse, CHO cells, H4 neuroglioma cells, Mouse brain.
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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
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