LPIN3 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
LPIN3 polyclonal antibody (Cat # PAB7126, 2.5 ug/mL) staining of paraffin embedded human thyroid gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of LPIN3.
Immunogen
A synthetic peptide corresponding to human LPIN3.
Sequence
C-KPKQKEDAVATD
Host
Goat
Theoretical MW (kDa)
93.5
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
LPIN3 polyclonal antibody (Cat # PAB7126, 2.5 ug/mL) staining of paraffin embedded human thyroid gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — LPIN3
Entrez GeneID
64900Protein Accession#
NP_075047.1Gene Name
LPIN3
Gene Alias
LIPN3L, SMP2, dJ450M14.2, dJ450M14.3, dJ620E11.2
Gene Description
lipin 3
Omim ID
605520Gene Ontology
HyperlinkGene Summary
Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy (fld) gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes (Lpin2 and Lpin3) and three human homologs (LPIN1, LPIN2, and LPIN3). Human LPIN1 gene has been mapped to 2p25.; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively. [provided by RefSeq
Other Designations
OTTHUMP00000031711|lipin 3-like
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Interactome
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Publication Reference
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The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth.
Santos-Rosa H, Leung J, Grimsey N, Peak-Chew S, Siniossoglou S.
The EMBO Journal 2005 Jun; 24(11):1931.
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The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth.
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