AGTR1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of AGTR1.
Immunogen
A synthetic peptide corresponding to human AGTR1.
Sequence
C-EIQKNKPRNDDIFK
Host
Goat
Theoretical MW (kDa)
41.1
Reactivity
Human, Mouse, Rat
Specificity
All reported variants represent identical protein (NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
AGTR1 polyclonal antibody (Cat # PAB7122) (0.3 ug/mL) staining of mouse liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AGTR1
Entrez GeneID
185Protein Accession#
NP_000676.1;NP_004826.2;NP_033611.1;NP_114038.1;NP_114438.1Gene Name
AGTR1
Gene Alias
AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R
Gene Description
angiotensin II receptor, type 1
Gene Ontology
HyperlinkGene Summary
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq
Other Designations
angiotensin receptor 1|angiotensin receptor 1B|type-1B angiotensin II receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Role of brain angiotensin AT1 receptor in the carbachol-induced natriuresis and expression of nNOS in the locus coeruleus and proximal convoluted tubule.
Wang M, Jiang CL, Wang CY, Yao QY.
Physiological Research 2007 Aug; 56(4):383.
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Role of brain angiotensin AT1 receptor in the carbachol-induced natriuresis and expression of nNOS in the locus coeruleus and proximal convoluted tubule.
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