ZMPSTE24 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ZMPSTE24.
Immunogen
A synthetic peptide corresponding to human ZMPSTE24.
Sequence
C-ERLQALKTMKQH
Host
Goat
Theoretical MW (kDa)
54.8
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ZMPSTE24 polyclonal antibody (Cat # PAB7114) (0.5 ug/mL) staining of human skin lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ZMPSTE24
Entrez GeneID
10269Protein Accession#
NP_005848.2Gene Name
ZMPSTE24
Gene Alias
FACE-1, FACE1, FLJ14968, STE24, Ste24p
Gene Description
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq
Other Designations
CAAX prenyl protease|OTTHUMP00000006394|farnesylated-proteins converting enzyme 1|prenyl protein-specific endoprotease 1|zinc metalloproteinase STE24
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Interactome
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Disease
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Publication Reference
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A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.
Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG.
Science 2006 Mar; 311(5767):1621.
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A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.
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