QKI polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
QKI polyclonal antibody (Cat # PAB7106) (0.3 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of QKI.
Immunogen
A synthetic peptide corresponding to human QKI.
Sequence
ETKEKPKPTPDY-C
Host
Goat
Theoretical MW (kDa)
37.7, 35.1, 36, 35.2
Reactivity
Mouse
Specificity
This antibody is expected to recognize all reported isoforms (NP_006766.1, NP_996735.1, NP_996736.1, NP_996737.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
QKI polyclonal antibody (Cat # PAB7106) (0.3 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — QKI
Entrez GeneID
9444Protein Accession#
NP_006766.1;NP_996735.1;NP_996736.1;NP_996737.1Gene Name
QKI
Gene Alias
DKFZp586I0923, Hqk, QK, QK1, QK3
Gene Description
quaking homolog, KH domain RNA binding (mouse)
Omim ID
609590Gene Ontology
HyperlinkGene Summary
QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]). QKI proteins regulate RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability (Lauriat et al., 2008 [PubMed 17918747]).[supplied by OMIM
Other Designations
OTTHUMP00000017581|OTTHUMP00000017582|OTTHUMP00000017583|RNA binding protein HQK|homolog of mouse quaking QKI (KH domain RNA binding protein)|quaking homolog, KH domain RNA binding
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Interactome
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Disease
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Publication Reference
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Function of quaking in myelination: regulation of alternative splicing.
Wu JI, Reed RB, Grabowski PJ, Artzt K.
PNAS 2002 Apr; 99(7):4233.
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Function of quaking in myelination: regulation of alternative splicing.
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