CHRM1 polyclonal antibody
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Specifications
Product Description
Goat polyclonal antibody raised against synthetic peptide of CHRM1.
Immunogen
A synthetic peptide corresponding to human CHRM1.
Sequence
C-DKRRWRKIPKRPGSVH
Host
Goat
Theoretical MW (kDa)
51.4
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CHRM1 polyclonal antibody (Cat # PAB7100) (1 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CHRM1
Entrez GeneID
1128Protein Accession#
NP_000729.2Gene Name
CHRM1
Gene Alias
HM1, M1, MGC30125
Gene Description
cholinergic receptor, muscarinic 1
Omim ID
118510Gene Ontology
HyperlinkGene Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq
Other Designations
muscarinic acetylcholine receptor M1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM.
Neuron 2006 Mar; 49(5):671.
Application:WB-Ti, Mouse, Mouse brain.
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M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
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