FBLN5 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
FBLN5 polyclonal antibody (Cat # PAB7098) (0.1 ug/mL) staining of human ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of FBLN5.
Immunogen
A synthetic peptide corresponding to human FBLN5.
Sequence
C-RPIKGPREIQLDLE
Host
Goat
Theoretical MW (kDa)
50.2
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
FBLN5 polyclonal antibody (Cat # PAB7098) (0.1 ug/mL) staining of human ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — FBLN5
Entrez GeneID
10516Protein Accession#
NP_006320.2Gene Name
FBLN5
Gene Alias
ARMD3, DANCE, EVEC, FIBL-5, FLJ90059, UP50
Gene Description
fibulin 5
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq
Other Designations
developmental arteries and neural crest epidermal growth factor-like|urine p50 protein
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Interactome
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Disease
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Publication Reference
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Fibulins 3 and 5 antagonize tumor angiogenesis in vivo.
Albig AR, Neil JR, Schiemann WP.
Cancer Research 2006 Mar; 66(5):2621.
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Fibulins 3 and 5 antagonize tumor angiogenesis in vivo.
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