KCNC3 polyclonal antibody
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Specifications
Product Description
Goat polyclonal antibody raised against synthetic peptide of KCNC3.
Immunogen
A synthetic peptide corresponding to human KCNC3.
Sequence
C-KPGPPSFLPDLNAN
Host
Goat
Theoretical MW (kDa)
80.5
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
KCNC3 polyclonal antibody (Cat # PAB7096) (0.3 ug/mL) staining of human brain (frontal cortex) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KCNC3
Entrez GeneID
3748Protein Accession#
NP_004968.2Gene Name
KCNC3
Gene Alias
KSHIIID, KV3.3, SCA13
Gene Description
potassium voltage-gated channel, Shaw-related subfamily, member 3
Gene Ontology
HyperlinkGene Summary
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. [provided by RefSeq
Other Designations
Shaw-related voltage-gated potassium channel protein 3|voltage-gated potassium channel protein KV3.3
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Interactomes
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Diseases
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Publication Reference
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Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes.
Waters MF, Minassian NA, Stevanin G, Figueroa KP, Bannister JP, Nolte D, Mock AF, Evidente VG, Fee DB, Muller U, Durr A, Brice A, Papazian DM, Pulst SM.
Nature Genetics 2006 Apr; 38(4):447.
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Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes.
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