CILP polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
CILP polyclonal antibody (Cat # PAB7075) (0.03 ug/mL) staining of rat spinal cord lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CILP.
Immunogen
A synthetic peptide corresponding to human CILP.
Sequence
C-NYRRTDHEDPRVK
Host
Goat
Theoretical MW (kDa)
133
Reactivity
Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CILP polyclonal antibody (Cat # PAB7075) (0.03 ug/mL) staining of rat spinal cord lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CILP
Entrez GeneID
8483Protein Accession#
NP_003604.2Gene Name
CILP
Gene Alias
CILP-1, HsT18872
Gene Description
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Gene Ontology
HyperlinkGene Summary
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase, however later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. One isoform of the protein, CILP-1, functions as an IGF-1 antagonist. [provided by RefSeq
Other Designations
cartilage intermediate layer protein|cartilage intermediate layer protein 1 C1|cartilage intermediate layer protein 1 C2
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Interactome
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Disease
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Publication Reference
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A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.
Seki S, Kawaguchi Y, Chiba K, Mikami Y, Kizawa H, Oya T, Mio F, Mori M, Miyamoto Y, Masuda I, Tsunoda T, Kamata M, Kubo T, Toyama Y, Kimura T, Nakamura Y, Ikegawa S.
Nature Genetics 2005 May; 37(6):607.
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A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.
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