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Last updated: 2017/3/26
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VHL polyclonal antibody

  • Catalog # : PAB7071
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of VHL.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human VHL.
  • Sequence:
  • C-RSLVKPENYRRLD
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 24.2, 19.7
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody is expected to recognize both reported isoforms (NP_000542.1 and NP_937799.1).
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:128000)
    Sandwhich ELISA (1.5-3 ug/mL)
    Western Blot (0.01-0.03 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • VHL polyclonal antibody (Cat # PAB7071) (0.01 ug/mL) staining of human ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • ELISA
  • Sandwich ELISA
  • Sandwich ELISA
  • VHL polyclonal antibody (Cat # PAB7071) (1.5 ug/mL) as the reporter as the capture rabbit antibody (2.5 ug/mL).
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 7428
  • Protein Accession#:
  • NP_000542.1;NP_937799.1
  • Gene Name:
  • VHL
  • Gene Alias:
  • HRCA1,RCA1,VHL1
  • Gene Description:
  • von Hippel-Lindau tumor suppressor
  • Gene Summary:
  • Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • elongin binding protein
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