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Last updated: 2016/12/11
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AIRE polyclonal antibody

  • Catalog # : PAB7040
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of AIRE.
  • Immunogen:
  • A synthetic peptide corresponding to human AIRE.
  • Sequence:
  • C-KDVDLSQPRKGRKP
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 57.7, 36.5
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is expected to recognize isoform 1 (NP_000374.1) only.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:32000)
    Western Blot (0.5-1 ug/mL)
    Immunohistochemistry (2.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • AIRE polyclonal antibody (Cat # PAB7040) (0.05 ug/mL) staining of HEK 293T (Bosc 23) lysates. Untransfected (Lane A) and transfected with human AIRE (lane B). Data kindly provided by Prof. Part Peterson, University of Tartu, Estonia.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • AIRE polyclonal antibody (Cat # PAB7040) (2.5 ug/mL) staining of paraffin embedded human thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 326
  • Gene Name:
  • AIRE
  • Gene Alias:
  • AIRE1,APECED,APS1,APSI,PGA1
  • Gene Description:
  • autoimmune regulator
  • Gene Summary:
  • This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). [provided by RefSeq
  • Other Designations:
  • autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
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