HTR1B polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HTR1B.
Immunogen
A synthetic peptide corresponding to human HTR1B.
Sequence
C-SNEDFKQAFHK
Host
Goat
Theoretical MW (kDa)
43.6
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
HTR1B polyclonal antibody (Cat # PAB7035) (2 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HTR1B
Entrez GeneID
3351Protein Accession#
NP_000854.1Gene Name
HTR1B
Gene Alias
5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
Gene Description
5-hydroxytryptamine (serotonin) receptor 1B
Omim ID
182131Gene Ontology
HyperlinkGene Summary
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of 4 main groups, 5-HT-1, 5-HT-2, 5-HT-3, and 5-HT4, subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM
Other Designations
OTTHUMP00000016769
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Interactome
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Pathway
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Disease
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Publication Reference
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Alterations in 5-HT1B receptor function by p11 in depression-like states.
Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, Vaugeois JM, Nomikos GG, Greengard P.
Science 2006 Jan; 311(5757):77.
Application:IP, WB-Tr, Human, Monkey, COS-7, HeLa cells.
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Alterations in 5-HT1B receptor function by p11 in depression-like states.
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