TTR polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TTR.
Immunogen
A synthetic peptide corresponding to human TTR.
Sequence
C-YKVEIDTKSYWK
Host
Goat
Theoretical MW (kDa)
15.9
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TTR
Entrez GeneID
7276Protein Accession#
NP_00.0362.1Gene Name
TTR
Gene Alias
HsT2651, PALB, TBPA
Gene Description
transthyretin
Omim ID
176300Gene Ontology
HyperlinkGene Summary
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq
Other Designations
prealbumin, amyloidosis type I|thyroxine-binding prealbumin
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Interactome
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Disease
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Publication Reference
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The biological and chemical basis for tissue-selective amyloid disease.
Sekijima Y, Wiseman RL, Matteson J, Hammarstrom P, Miller SR, Sawkar AR, Balch WE, Kelly JW.
Cell 2005 Apr; 121(1):73.
Application：ELISA, IF, Mouse, BHK cells.
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The biological and chemical basis for tissue-selective amyloid disease.
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