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AKR1C4 polyclonal antibody

  • Catalog # : PAB7023
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of AKR1C4.
  • Immunogen:
  • A synthetic peptide corresponding to human AKR1C4.
  • Sequence:
  • DPKYQRVELNDGH-C
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 37.1
  • Reactivity:
  • Human
  • Specificity:
  • This antibody may cross-react with AKR1C1.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:4000)
    Western blot (0.1-0.3 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • AKR1C4 polyclonal antibody (Cat # PAB7023) (0.1 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • AKR1C4 polyclonal antibody (Cat # PAB7023, 2.5 ug/mL) staining of paraffin embedded human liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1109
  • Gene Name:
  • AKR1C4
  • Gene Alias:
  • 3-alpha-HSD,C11,CDR,CHDR,DD4,HAKRA,MGC22581
  • Gene Description:
  • aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
  • Gene Summary:
  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
  • Other Designations:
  • 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4,OTTHUMP00000018997,aldo-keto reductase family 1, member C4,chlordecone reductase,dihydrodiol dehydrogenase 4,dihydrodiol dehydrogenase isozyme DD4,type I 3-alpha-hydroxysteroid dehydrogenase
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