TSC1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TSC1.
Immunogen
A synthetic peptide corresponding to human TSC1.
Sequence
C-QLHIMDYNETHHEH
Host
Goat
Theoretical MW (kDa)
130
Reactivity
Human
Specificity
This antibody is expected to recognize isoform 1 (NP_00.0359.1) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TSC1 polyclonal antibody (Cat # PAB7016) (0.1 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Transfected lysate)
HEK293 overexpressing human TSC1 and probed with TSC1 polyclonal antibody (Cat # PAB7016) (mock transfection in first lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TSC1
Entrez GeneID
7248Protein Accession#
NP_00.0359.1Gene Name
TSC1
Gene Alias
KIAA0243, LAM, MGC86987, TSC
Gene Description
tuberous sclerosis 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000022439|hamartin|tuberous sclerosis 1 protein|tumor suppressor
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Interactome
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Pathway
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Disease
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Publication Reference
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Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.
Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ.
Journal of Neuropathology and Experimental Neurology 2004 Dec; 63(12):1236.
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Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.
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