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Last updated: 2017/11/19
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CYP17A1 polyclonal antibody

  • Catalog # : PAB7014
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of CYP17A1.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human CYP17A1.
  • Sequence:
  • C-LFKDGDQKLEK
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 57.4
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:64000)
    Western Blot (0.1-0.3 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • CYP17A1 polyclonal antibody (Cat # PAB7014) (0.3 ug/mL) staining of human ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • CYP17A1 polyclonal antibody (Cat # PAB7014) (3.8 ug/mL) staining of paraffin embedded human adrenal gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1586
  • Gene Name:
  • CYP17A1
  • Gene Alias:
  • CPT7,CYP17,P450C17,S17AH
  • Gene Description:
  • cytochrome P450, family 17, subfamily A, polypeptide 1
  • Gene Summary:
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000020382,cytochrome P450, family 17,cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia,cytochrome p450 XVIIA1,steroid 17-alpha-hydroxylase/17,20 lyase,steroid 17-alpha-monooxygenase
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