BMPR1A polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of BMPR1A.
Immunogen
A synthetic peptide corresponding to human BMPR1A.
Sequence
C-KSDSDQKKSEN
Host
Goat
Theoretical MW (kDa)
60.2
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
BMPR1A polyclonal antibody (Cat # PAB7002) (1 ug/mL) staining of HeLa cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BMPR1A
Entrez GeneID
657Protein Accession#
NP_004320.2Gene Name
BMPR1A
Gene Alias
10q23del, ACVRLK3, ALK3, CD292
Gene Description
bone morphogenetic protein receptor, type IA
Gene Ontology
HyperlinkGene Summary
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq
Other Designations
OTTHUMP00000020014|activin A receptor, type II-like kinase 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Molecular recognition of BMP-2 and BMP receptor IA.
Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD.
Nature Structural & Molecular Biology 2004 May; 11(5):481.
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Molecular recognition of BMP-2 and BMP receptor IA.
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