TRAF1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TRAF1.
Immunogen
A synthetic peptide corresponding to human TRAF1.
Sequence
C-KLQSPKHAYVKDD
Host
Goat
Theoretical MW (kDa)
46.2
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
TRAF1 polyclonal antibody (Cat # PAB6988) (0.5 ug/mL) staining of U-937 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TRAF1
Entrez GeneID
7185Protein Accession#
NP_005649.1Gene Name
TRAF1
Gene Alias
EBI6, MGC:10353
Gene Description
TNF receptor-associated factor 1
Omim ID
601711Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. [provided by RefSeq
Other Designations
Epstein-Bar virus-induced protein 6|OTTHUMP00000022000
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Interactome
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Pathway
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Disease
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Publication Reference
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TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling.
Su X, Li S, Meng M, Qian W, Xie W, Chen D, Zhai Z, Shu HB.
European Journal of Immunology 2006 Jan; 36(1):199.
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TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling.
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