OSCAR polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of OSCAR.
Immunogen
A synthetic peptide corresponding to human OSCAR.
Sequence
C-EGPEARPASSAP
Host
Goat
Theoretical MW (kDa)
30.9,
Specificity
This antibody is expected to recognize isoform 1 (NP_996554.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — OSCAR
Entrez GeneID
126014Protein Accession#
NP_996554.1Gene Name
OSCAR
Gene Alias
MGC33613, PIGR3
Gene Description
osteoclast associated, immunoglobulin-like receptor
Omim ID
606862Gene Ontology
HyperlinkGene Summary
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000067452|osteoclast associated receptor OSCAR-S1|osteoclast associated receptor OSCAR-S2|osteoclast-associated receptor|polymeric immunoglobulin receptor 3
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Publication Reference
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Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.
Kim K, Kim JH, Lee J, Jin HM, Lee SH, Fisher DE, Kook H, Kim KK, Choi Y, Kim N.
The Journal of Biological Chemistry 2005 Oct; 280(42):35209.
Application：WB-Ce, Mouse, BMMs.
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Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.
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