PTGER1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PTGER1.
Immunogen
A synthetic peptide corresponding to human PTGER1.
Sequence
C-DSRRRWGAHGPRS
Host
Goat
Theoretical MW (kDa)
41.8
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTGER1
Entrez GeneID
5731Protein Accession#
NP_000946.2Gene Name
PTGER1
Gene Alias
EP1
Gene Description
prostaglandin E receptor 1 (subtype EP1), 42kDa
Omim ID
176802Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq
Other Designations
PGE receptor, EP1 subtype|prostaglandin E receptor 1, subtype EP1|prostanoid EP1 receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.
Han C, Wu T.
The Journal of Biological Chemistry 2005 Jun; 280(25):24053.
Application:IP-WB, WB-Ce, WB-Tr, Human, CCLP1, SG231, HuCCT1 cells.
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Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.
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