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PDE4B polyclonal antibody

  • Catalog # : PAB6965
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of PDE4B.
  • Immunogen:
  • A synthetic peptide corresponding to human PDE4B.
  • Sequence:
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 83.3, 64.4, 82.1
  • Reactivity:
  • Mouse
  • Specificity:
  • This antibody is expected to recognize all reported isoforms (NP_002591.2, NP_0010.32418.1, NP_0010.32416.1 and NP_0010.32417.1).
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:8000)
    Western Blot (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • PDE4B polyclonal antibody (Cat # PAB6965) (0.5 ug/mL) staining of mouse brain Lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • HEK293 overexpressing human PDE4B and probed with PDE4B polyclonal antibody (Cat # PAB6965) (mock transfection in first lane), tested by Origene.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5142
  • Protein Accession#:
  • NP_002591.2;NP_0010.32418.1;NP_0010.32416.1;NP_0010.32417.1
  • Gene Name:
  • PDE4B
  • Gene Alias:
  • DKFZp686F2182,DPDE4,MGC126529,PDE4B5,PDEIVB
  • Gene Description:
  • phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
  • Gene Summary:
  • This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000010652,OTTHUMP00000010656,OTTHUMP00000046896,cAMP-specific 3',5'-cyclic phosphodiesterase 4B,cAMP-specific phosphodiesterase-4 B isoform,dunce-like phosphodiesterase E4,phosphodiesterase 4B, cAMP-specific,phosphodiesterase 4B, cAMP-specific (d
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