IL6R polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of IL6R.
Immunogen
A synthetic peptide corresponding to human IL6R.
Sequence
C-DNTSSHNRPDARD
Host
Goat
Theoretical MW (kDa)
51.5
Specificity
This antibody is expected to recognize isoform 1 only (NP_000556.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL6R
Entrez GeneID
3570Protein Accession#
NP_000556.1Gene Name
IL6R
Gene Alias
CD126, IL-6R-1, IL-6R-alpha, IL6RA, MGC104991
Gene Description
interleukin 6 receptor
Omim ID
147880Gene Ontology
HyperlinkGene Summary
Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
CD126 antigen|OTTHUMP00000034320|interleukin 6 receptor alpha subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma.
Moran DM, Mayes N, Koniaris LG, Cahill PA, McKillop IH.
Liver International 2005 Apr; 25(2):445.
Application:WB-Ti, Rat, Hepatocellular carcinoma, Liver.
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Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma.
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