LAMA3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of LAMA3.
Immunogen
A synthetic peptide corresponding to human LAMA3.
Sequence
NNQCHSSHKRRTK
Host
Goat
Theoretical MW (kDa)
367
Specificity
This antibody is expected to recognize isoform 1 (NP_937762.1) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — LAMA3
Entrez GeneID
3909Protein Accession#
NP_937762.1Gene Name
LAMA3
Gene Alias
BM600, E170, LAMNA, LOCS, lama3a
Gene Description
laminin, alpha 3
Gene Ontology
HyperlinkGene Summary
Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
BM600 150kD subunit|epiligrin 170 kda subunit|epiligrin alpha 3 subunit|kalinin 165kD subunit|laminin alpha 3 subunit|laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)|laminin-5 alpha 3 chain|nicein 150kD subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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CREB-binding protein regulates apoptosis and growth of HMECs grown in reconstituted ECM via laminin-5.
Dietze EC, Bowie ML, Mrozek K, Caldwell LE, Neal C, Marjoram RJ, Troch MM, Bean GR, Yokoyama KK, Ibarra CA, Seewaldt VL.
Journal of Cell Science 2005 Nov; 118(Pt 21):5005.
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CREB-binding protein regulates apoptosis and growth of HMECs grown in reconstituted ECM via laminin-5.
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