PPIA polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
PPIA polyclonal antibody (Cat # PAB6935) (2 ug/mL) staining of human lymph node lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PPIA.
Immunogen
A synthetic peptide corresponding to human PPIA.
Sequence
C-ERFGSRNGKTSKK
Host
Goat
Theoretical MW (kDa)
18
Reactivity
Human
Specificity
This antibody is expected to recognize both isoform 1 (NP_066953.1) and isoform 2 (NP_982254.1 and NP_982255.1). This product is expected to recognize PPIAL (NP_001008741.1, GeneID: 388817) which is identical to isoform 1 (NP_066953.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PPIA polyclonal antibody (Cat # PAB6935) (2 ug/mL) staining of human lymph node lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PPIA
Entrez GeneID
5478Protein Accession#
NP_066953.1;NP_982254.1;NP_982255.1Gene Name
PPIA
Gene Alias
CYPA, CYPH, MGC117158, MGC12404, MGC23397
Gene Description
peptidylprolyl isomerase A (cyclophilin A)
Omim ID
123840Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000025305|PPIase A|T cell cyclophilin|cyclosporin A-binding protein|peptidyl-prolyl cis-trans isomerase A|peptidylprolyl isomerase A|rotamase A
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Interactome
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Disease
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Publication Reference
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Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells.
Berthoux L, Sebastian S, Sokolskaja E, Luban J.
PNAS 2005 Oct; 102(41):14849.
Application：WB-Tr, Monkey, Vero, FRhK4 cells.
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Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells.
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