ROBO1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ROBO1.
Immunogen
A synthetic peptide corresponding to human ROBO1.
Sequence
C-GDVDLSNKINEMK
Host
Goat
Theoretical MW (kDa)
181, 177, 176, 170
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_002932.1; NP_598334.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
ROBO1 polyclonal antibody (Cat # PAB6930) (1 ug/mL) staining of HUVEC lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ROBO1
Entrez GeneID
6091Protein Accession#
NP_002932.1;NP_598334.1Gene Name
ROBO1
Gene Alias
DUTT1, FLJ21882, MGC131599, MGC133277, SAX3
Gene Description
roundabout, axon guidance receptor, homolog 1 (Drosophila)
Omim ID
602430Gene Ontology
HyperlinkGene Summary
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
axon guidance receptor|roundabout 1
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Interactome
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Pathway
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Disease
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Publication Reference
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The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia.
Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, Eklund R, Nopola-Hemmi J, Kaariainen H, Kere J.
PLoS Genetics 2005 Oct; 1(4):e50.
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The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia.
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