PDE4D polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PDE4D.
Immunogen
A synthetic peptide corresponding to C-terminus of human PDE4D.
Sequence
QPEACVIDDRSPDT
Host
Goat
Theoretical MW (kDa)
91.1, 76.5, 84.7
Reactivity
Human, Mouse
Specificity
This antibody is not expected to recognize isoform 4.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 overexpressing human PDE4D2 and probed with PDE4D polyclonal antibody (Cat # PAB6924) (mock transfection in first lane), tested by Origene.Western Blot (Transfected lysate)
PDE4D polyclonal antibody (Cat # PAB6924) staining (1 ug/mL) of COS cell lysates (25 ug protein) : transfected with human PDE4D1 (1), transfected with human PDE4D3 (2), untransfected (3). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PDE4D
Entrez GeneID
5144Protein Accession#
NP_001098101.1;NP_006194.2;NP_001159371.1Gene Name
PDE4D
Gene Alias
DPDE3, HSPDE4D, PDE4DN2, STRK1
Gene Description
phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins
Other Designations
cAMP-specific phosphodiesterase 4D|cAMP-specific phosphodiesterase PDE4D6|dunce-like phosphodiesterase E3|phosphodiesterase 4D, cAMP-specific (dunce
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Interactome
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Pathway
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Disease
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Publication Reference
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The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target.
Houslay MD.
Molecular Pharmacology 2005 Sep; 68(3):563.
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The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target.
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