PAX8 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
PAX8 polyclonal antibody (Cat # PAB6919) (0.5 ug/mL) staining of 293 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PAX8.
Immunogen
A synthetic peptide corresponding to human PAX8.
Sequence
C-AQPGSDKRKMDD
Host
Goat
Theoretical MW (kDa)
48.2, 41.7, 43, 34.9
Reactivity
Human
Specificity
This antibody is expected to recognize all reported isoforms (NP_0.03457.1, NP_0.39245.1, NP_0.39246.1, NP_0.39247.1, NP_054698.1)
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
PAX8 polyclonal antibody (Cat # PAB6919) (0.5 ug/mL) staining of 293 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PAX8
Entrez GeneID
7849Protein Accession#
NP_0.03457.1;NP_0.39245.1;NP_0.39246.1;NP_0.39247.1;NP_054698.1Gene Name
PAX8
Gene Alias
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Gene Description
paired box 8
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternateively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000158659|OTTHUMP00000158660|paired domain gene 8
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Interactome
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Pathway
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Disease
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Publication Reference
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PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.
Castro P, Rebocho AP, Soares RJ, Magalhaes J, Roque L, Trovisco V, Vieira de Castro I, Cardoso-de-Oliveira M, Fonseca E, Soares P, Sobrinho-Simoes M.
The Journal of Clinical Endocrinology and Metabolism 2006 Jan; 91(1):213.
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PAX8-PPARgamma rearrangement is frequently detected in the follicular variant of papillary thyroid carcinoma.
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