NOTCH3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NOTCH3.
Immunogen
A synthetic peptide corresponding to C-terminus of human NOTCH3.
Sequence
C-QLGPQPEVTPKRQ
Host
Goat
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NOTCH3 polyclonal antibody (4 ug/mL) staining of paraffin embedded human hippocampus. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NOTCH3
Entrez GeneID
4854Protein Accession#
NP_000426.2Gene Name
NOTCH3
Gene Alias
CADASIL, CASIL
Gene Description
Notch homolog 3 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq
Other Designations
Notch homolog 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Notch3 signaling initiates choroid plexus tumor formation.
Dang L, Fan X, Chaudhry A, Wang M, Gaiano N, Eberhart CG.
Oncogene 2006 Jan; 25(3):487.
Application:IHC, Human, Mouse, Choroid plexus papillomas.
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Notch3 signaling initiates choroid plexus tumor formation.
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