NOTCH2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NOTCH2.
Immunogen
A synthetic peptide corresponding to human NOTCH2.
Sequence
C-ERTPSHSGHLQGEH
Host
Goat
Theoretical MW (kDa)
265
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NOTCH2
Entrez GeneID
4853Protein Accession#
NP_077719.2Gene Name
NOTCH2
Gene Alias
AGS2, hN2
Gene Description
Notch homolog 2 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. [provided by RefSeq
Other Designations
OTTHUMP00000014035|OTTHUMP00000059536|notch 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia.
Schwarzmeier JD, Hubmann R, Duchler M, Jager U, Shehata M.
Leukemia & Lymphoma 2005 Feb; 46(2):157.
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Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia.
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