FZD8 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of FZD8.
Immunogen
A synthetic peptide corresponding to human FZD8.
Sequence
C-SYPKQMPLSQV
Host
Goat
Theoretical MW (kDa)
73.3
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
Immunohistochemistry (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
FZD8 polyclonal antibody (Cat # PAB6916) (1 ug/mL) staining of human pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
FZD8 polyclonal antibody (Cat # PAB6916) (3 ug/mL) staining of paraffin embedded human pancreas. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-Enzyme-linked Immunoabsorbent Assay
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Gene Info — FZD8
Entrez GeneID
8325Protein Accession#
NP_114072.1Gene Name
FZD8
Gene Alias
FZ-8, hFZ8
Gene Description
frizzled homolog 8 (Drosophila)
Omim ID
606146Gene Ontology
HyperlinkGene Summary
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq
Other Designations
OTTHUMP00000019454|frizzled 8
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Interactome
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Pathway
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Disease
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Publication Reference
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An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide.
Keay SK, Szekely Z, Conrads TP, Veenstra TD, Barchi JJ Jr, Zhang CO, Koch KR, Michejda CJ.
PNAS 2004 Aug; 101(32):11803.
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An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide.
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