TNFRSF14 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TNFRSF14.
Immunogen
A synthetic peptide corresponding to human TNFRSF14.
Sequence
C-SVQRKRQEAEGE
Host
Goat
Theoretical MW (kDa)
30.4
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.03-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TNFRSF14 polyclonal antibody (Cat # PAB6910) (0.03 ug/mL) staining of human thymus lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TNFRSF14
Entrez GeneID
8764Protein Accession#
NP_0.03811.2Gene Name
TNFRSF14
Gene Alias
ATAR, HVEA, HVEM, LIGHTR, TR2
Gene Description
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Omim ID
602746Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. [provided by RefSeq
Other Designations
CD40-like protein|OTTHUMP00000000866|herpesvirus entry mediator A|tumor necrosis factor receptor superfamily, member 14|tumor necrosis factor receptor-like gene2
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Interactome
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Pathway
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Disease
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Publication Reference
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Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.
Cheung TC, Humphreys IR, Potter KG, Norris PS, Shumway HM, Tran BR, Patterson G, Jean-Jacques R, Yoon M, Spear PG, Murphy KM, Lurain NS, Benedict CA, Ware CF.
PNAS 2005 Sep; 102(37):13218.
Application:Flow Cyt, Human, 293T cells.
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Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.
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