EYA4 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of EYA4.
Immunogen
A synthetic peptide corresponding to human EYA4.
Sequence
EDSQDLNEQSVKKTC
Host
Goat
Theoretical MW (kDa)
69.5, 67.1, 69.4
Specificity
This antibody is expected to recognize isoforms a, c and d (NP_004091.2, NP_742102.1 and NP_74210.3.1 respectively).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — EYA4
Entrez GeneID
2070Protein Accession#
NP_004091.3;NP_742102.2;NP_74210.3.1Gene Name
EYA4
Gene Alias
CMD1J, DFNA10
Gene Description
eyes absent homolog 4 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant nonsyndromic sensorineural 10 locus. Defects in this gene are also associated with dilated cardiomyopathy 1J. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000017235|OTTHUMP00000040267|dJ78N10.1 (eyes absent|eyes absent 4
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Interactome
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Disease
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Publication Reference
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Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.
Schonberger J, Wang L, Shin JT, Kim SD, Depreux FF, Zhu H, Zon L, Pizard A, Kim JB, Macrae CA, Mungall AJ, Seidman JG, Seidman CE.
Nature Genetics 2005 Apr; 37(4):418.
Application：ISH, Zebrafish, Heart.
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Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.
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