IDO1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
IDO1 polyclonal antibody (Cat # PAB6880) (4 ug/mL) staining of paraffin embedded human colon. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of IDO1.
Immunogen
A synthetic peptide corresponding to internal region of human IDO1.
Sequence
CVLANWKKKDPNK
Host
Goat
Theoretical MW (kDa)
45.3
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
IDO1 polyclonal antibody (Cat # PAB6880) (4 ug/mL) staining of paraffin embedded human colon. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IDO1
Entrez GeneID
3620Protein Accession#
NP_002155.1Gene Name
IDO1
Gene Alias
CD107B, IDO, INDO
Gene Description
indoleamine 2,3-dioxygenase 1
Omim ID
147435Gene Ontology
HyperlinkGene Summary
Gamma-interferon (IFNG; MIM 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO; EC 1.13.11.52). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine.[supplied by OMIM
Other Designations
indole 2,3-dioxygenase|indoleamine-pyrrole 2,3 dioxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.
Munn DH, Sharma MD, Baban B, Harding HP, Zhang Y, Ron D, Mellor AL.
Immunity 2005 May; 22(5):633.
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GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.
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