ENPP1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ENPP1.
Immunogen
A synthetic peptide corresponding to C-terminus of human ENPP1.
Sequence
C-KTHLPTFSQED
Host
Goat
Theoretical MW (kDa)
105
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western blot (1-3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 overexpressing Human ENPP1 and probed with ENPP1 polyclonal antibody (Cat # PAB6879) (mock transfection in first lane) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ENPP1 polyclonal antibody (Cat # PAB6879) (1 ug/mL) staining of paraffin embedded human liver. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ENPP1
Entrez GeneID
5167Protein Accession#
NP_006199.2Gene Name
ENPP1
Gene Alias
M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1
Gene Description
ectonucleotide pyrophosphatase/phosphodiesterase 1
Gene Ontology
HyperlinkGene Summary
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq
Other Designations
Ly-41 antigen|OTTHUMP00000043194|alkaline phosphodiesterase 1|membrane component, chromosome 6, surface marker 1|phosphodiesterase I/nucleotide pyrophosphatase 1|plasma-cell membrane glycoprotein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice.
Bertrand J, Nitschke Y, Fuerst M, Hermann S, Schäfers M, Sherwood J, Nalesso G, Ruether W, Rutsch F, Dell'Accio F, Pap T.
Annals of the Rheumatic Diseases 2012 Jul; 71(7):1249.
Application:IHC, Human, Mouse , Human cartilage samples, Mouse knee joint sections.
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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clement K, Jouret B, Weill J, Maddux BA, Goldfine ID, Walley A, Boutin P, Dina C, Froguel P.
Nature Genetics 2005 Aug; 37(8):863.
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Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice.
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