PCK1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PCK1.
Immunogen
A synthetic peptide corresponding to human PCK1.
Sequence
C-HVNWFRKDKEGK
Host
Goat
Theoretical MW (kDa)
69.2
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
PCK1 polyclonal antibody (Cat # PAB6874) (2 ug/mL) staining of paraffin embedded human cerebral cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PCK1
Entrez GeneID
5105Protein Accession#
NP_002582.2Gene Name
PCK1
Gene Alias
MGC22652, PEPCK-C, PEPCK1, PEPCKC
Gene Description
phosphoenolpyruvate carboxykinase 1 (soluble)
Omim ID
261680Gene Ontology
HyperlinkGene Summary
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000031374|PEP carboxykinase|cytosolic phosphoenolpyruvate carboxykinase 1|phosphoenolpyruvate carboxylase|phosphopyruvate carboxylase
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Interactome
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Pathway
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Disease
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Publication Reference
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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.
Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB.
Nature 2005 Jul; 436(7049):356.
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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.
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