LDB3 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of LDB3.
Immunogen
A synthetic peptide corresponding to internal region of human LDB3.
Sequence
C-KSQNKPEDEADE
Host
Goat
Theoretical MW (kDa)
77.1
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:2000)
Western Blot (0.01-0.03 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
LDB3 polyclonal antibody (Cat # PAB6864) (0.01 ug/mL) staining of human muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
LDB3 polyclonal antibody (Cat # PAB6864) (3.8 ug/mL) staining of paraffin embedded human skeletal muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — LDB3
Entrez GeneID
11155Protein Accession#
NP_009009.1;NP_001073583.1;NP_001073584.1;NP_001073585.1Gene Name
LDB3
Gene Alias
CYPHER, FLJ35865, KIAA01613, KIAA0613, ORACLE, PDLIM6, ZASP, ldb3z1, ldb3z4
Gene Description
LIM domain binding 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1 and 2) have C-terminal LIM domains. [provided by RefSeq
Other Designations
OTTHUMP00000020008|OTTHUMP00000020009|PDZ and LIM domain 6
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Interactome
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Disease
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Publication Reference
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Mutations in ZASP define a novel form of muscular dystrophy in humans.
Selcen D, Engel AG.
Annals of Neurology 2005 Feb; 57(2):269.
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Mutations in ZASP define a novel form of muscular dystrophy in humans.
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