MMP7 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MMP7.
Immunogen
A synthetic peptide corresponding to human MMP7.
Sequence
C-QKLYGKRSNSRKK
Host
Goat
Theoretical MW (kDa)
29.7
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.03-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
MMP7 polyclonal antibody (Cat # PAB6849) (0.03 ug/mL) staining of human breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP7
Entrez GeneID
4316Protein Accession#
NP_002414.1Gene Name
MMP7
Gene Alias
MMP-7, MPSL1, PUMP-1
Gene Description
matrix metallopeptidase 7 (matrilysin, uterine)
Omim ID
178990Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
matrin|matrix metalloproteinase 7|matrix metalloproteinase 7 (matrilysin, uterine)|uterine matrilysin
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Interactome
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Pathway
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Disease
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Publication Reference
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Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis.
Li YJ, Wei ZM, Meng YX, Ji XR.
World Journal of Gastroenterology 2005 Apr; 11(14):2117.
Application:IHC-P, Human, Pancreatic cancer.
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Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis.
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